Search Path: MendelBase Query: ^cubilin *| Legend: Attribute :: answer :: comment :: PubMed ID :: Species

cubilin Expression Information Serial Analysis of Gene Expression [SAGE] :: Yes :: SAGE library data ::  :: Homo sapiens  Expression Information / Subcellular Localization Plasma membrane-associated :: Yes :: The N-terminal cubilin region seems crucial for membrane association. A conserved amphipathic helix pattern (Lys74-Glu109) as a candidate site for hydrophobic interactions. :: 10400683 :: Rattus  Expression Information / Tissue Localization Adult/Urogenital/Efferent duct :: Yes :: Cubilin mRNA is expressed in the efferent ducts, corpus and cauda epididymis, and proximal and distal vas deferens. :: 12506344 :: Rattus  Adult/Urogenital/Epididymis :: Yes :: Cubilin mRNA is expressed in the efferent ducts, corpus and cauda epididymis, and proximal and distal vas deferens. :: 12506344 :: Rattus  Adult/Urogenital/Vas Deferens :: Yes :: Cubilin mRNA is expressed in the efferent ducts, corpus and cauda epididymis, and proximal and distal vas deferens. :: 12506344 :: Rattus  Embryo/Extraembryonic/Yolk Sac/Visceral Endoderm :: Yes ::  :: 10766831 :: Mus musculus  Functional Information / Binds to or Interacts with Lipoprotein/HDL :: Yes ::  :: 10468579 :: Mus musculus  Protein/Name of protein that it binds :: albumin :: cubilin, working in conjunction with the endocytic receptor megalin, mediates albumin reabsorption by renal proximal tubule cells. :: 10811843 :: Rattus    "    :: apolipoprotein-AI (apoAI, apoA-I) :: Cubilin is a receptor in epithelial apoA-I/HDL metabolism. :: 10371504 :: Rattus    "    :: cation-independent mannose 6-phosphate/insulin-like growth factor II-receptor (CIMPR) ::  :: 12121845 :: Rattus    "    :: Clara cell secretory protein; uteroglobin (UGB) ::  :: 11278724 :: Rattus    "    :: Clara cell secretory protein :: Clara cell secretory protein (CCSP) is a transport protein for lipophilic substances in bronchio-alveolar fluid, plasma, and uterine secretion.NP_037183 :: 11278724 :: Rattus    "    :: galectin-3 ::  :: 11856751 :: Mus musculus    "    :: intrinsic factor-cobalamin; intrinsic factor-vitamin B12 ::  :: 9153271 :: Rattus    "    :: megalin ::  :: 9478979 :: Rattus    "    :: myoglobin :: This interaction is important for myoglobin uptake in the renal proximal tubule. :: 12724130 :: Mus musculus    "    :: transferrin (Tf) :: cubilin, working in conjunction with the endocytic receptor megalin, mediates endocytosis of Tf. The two receptors thereby facilitate iron uptake in kidney proximal tubules and perhaps other tissues that express both receptors. :: 11606717 :: Mus musculus    "    :: vitamin D-binding protein (DBP) :: Kd = 129 nM :: 11717447 :: Rattus  Functional Information / Functions in biological process of Transport or Trafficking/Endocytosis :: Yes ::  :: 11375443 :: Rattus  Transport or Trafficking/Lipoprotein :: Yes :: cubilin in conjunction with megalin mediates endocytosis of high density lipoproteins (HDL). :: 10766831 :: Mus musculus  Transport or Trafficking/Vitamin :: Yes :: cubilin acts in conjunction with megalin to mediate renal uptake of 25(OH) vitamin D(3). :: 11717447 :: Homo sapiens  Vitamin metabolism :: Yes :: cubilin in conjunction with megalin mediates endocytosis of intrinsic factor-vitamin B12 and 25(OH) vitamin D(3). :: 11717447 :: Homo sapiens  General Information / Protein name Synonym :: intrinsic factor B12-receptor; intrinsic factor-cobalamin receptor; IFCR, MGA1, GP280 ::  ::  :: Rattus  Genetic Information cDNA sequence ID numbers :: AF197159.1 GI:7381453 :: AF197159.1 GI:7381453 ::  :: Mus musculus    "    :: NM_001081.1 GI:4557502 :: NM_001081.1 GI:4557502 :: 98241400 :: Homo sapiens  Chromosomal localization :: 10p12.1 ::  :: 7573042 :: Homo sapiens  Gene symbol [map element] :: CUBN, IFCR, MGA1 :: CUBN ::  :: Homo sapiens    "    :: CUBN, IFCR, MGA1 :: CUBN ::  :: Homo sapiens  LocusLink ID number :: 65969 :: 65969 ::  :: Mus musculus    "    :: 8029 :: 8029 ::  :: Homo sapiens  Genetic Information / Mutations Disease or anomaly :: Yes :: MEGALOBLASTIC ANEMIA 1; MGA1; #261100 :: 10080186 :: Homo sapiens  Genetic Information OMIM number :: *602997 :: *602997 ::  :: Homo sapiens  UniGene cluster number :: Hs.166206 :: Hs.166206 ::  :: Homo sapiens    "    :: Mm.2735 :: Mm.2735 ::  :: Mus musculus  Structural Information Modular domain structure :: CUB, CUB domain (27) :: pfam00431 :: 9572993 :: Homo sapiens  Record Count: 35 Contributors: Scott Argraves; Total Protein Count: 1 Total Record Count: 35 Please review our Disclaimers and Terms of Use Agreements. Copyright 2000 Array Genetics, Inc., All Rights Reserved.