| Expression Information / Secreted |
- Blood/Plasma concentration [mg per ml] :: 0.033 mg/ml :: :: 2269669 :: Homo sapiens
- Extracellular matrix protein/Basement membrane protein :: Yes :: :: 1601179 :: Gallus gallus
- " :: Yes :: :: 8850569 :: Mus musculus
- Extracellular matrix protein/Matrix fiber protein :: Yes :: :: 7534784 :: Homo sapiens
|
| Expression Information |
- Serial Analysis of Gene Expression [SAGE] :: Yes :: SAGE library data :: :: Homo sapiens
|
| Expression Information / Tissue Localization |
- Adult/Bone :: Yes :: bone marrow stroma :: 10848816 :: Homo sapiens
- Adult/Skin/Dermis :: Yes :: fine fibrils :: 10594729 :: Mus musculus
- Embryo/Intraembryonic/Brain Embryonic/Choroid plexus :: Yes :: :: 8850569 :: Mus musculus
- Embryo/Intraembryonic/Brain Embryonic/Meninges :: Yes :: :: 8850569 :: Mus musculus
- Embryo/Intraembryonic/Cardiovascular/Endocardial Cushion :: Yes :: :: 1601179 :: Gallus gallus
- " :: Yes :: :: 8694289 :: Gallus gallus
- Embryo/Intraembryonic/Cardiovascular/Endocardium :: Yes :: :: 7851641 :: Mus musculus
- Embryo/Intraembryonic/Neural Crest Cells :: Yes :: :: 1601179 :: Gallus gallus
- Embryo/Intraembryonic/Neuroepithelium :: Yes :: In basement membranes of the neuroepithelium of human embryos of gestational weeks 4-10 :: 8737292 :: Homo sapiens
- Pathological/Tumor/Ovarian :: Yes :: fibulin-1 was located in the stroma of several ovarian cancers and cysts :: 8552629 :: Homo sapiens
|
| Functional Information / Binds to or Interacts with |
- Metal/Calcium :: Yes :: :: 2527614 :: Homo sapiens
- " :: Yes :: :: 8354280 :: Mus musculus
- Protein/Name of protein that it binds :: aggrecan :: fibulin-1A Kd = 19 nM; fibulin-1C Kd = 9 nM; fibulin-1D Kd = 10 nM; calcium-dependent binding :: 10400671 :: Homo sapiens
- " :: beta-amyloid precursor protein :: APP :: 11238726 :: Homo sapiens
- " :: endostatin :: endostatin (type XVIII collagen alpha 1) NP_08505 :: 9687493 :: Homo sapiens
- " :: fibrinogen :: :: 7642629 :: Homo sapiens
- " :: fibronectin :: Kd = 300 nM; binding site contained within type III module 13 of fibronectin :: 1400330 :: Homo sapiens
- " :: heparin-binding EGF-like growth factor precursor :: The fibulin-1C variant interacts with the extracellular domain of the heparin-binding EGF-like growth factor precursor. :: 11846885 :: Homo sapiens
- " :: laminin alpha 2 chain :: The mouse laminin alpha2 chain consists of five lamin-type G domain (LG) modules (alpha2LG1 to alpha2LG5). Fragments containing alpha2LG1-3 and alpha2LG4-5 bound to fibulin-1. :: 11564885 :: Mus musculus
- " :: laminin AmB1sB2e :: calcium-dependent binding :: 8175920 :: Mus musculus
- " :: laminin-5 :: :: 11733994 :: Mus musculus
- " :: nidogen :: :: 9299350 :: Mus musculus
- " :: NOVH :: binds fibulin 1C :: 9927660 :: Mus musculus
- " :: papillomavirus E6 protein :: :: 12200142 :: Mus musculus
- " :: tropoelastin :: :: 10544250 :: Homo sapiens
- " :: versican :: The binding site for aggrecan and versican lectin domains was mapped to the epidermal growth factor-like repeats in domain II of fibulin-1. :: 10400671 :: Mus musculus
|
| Functional Information / Functions as |
- Adhesive protein/Promotes attachment :: Yes :: Mediates attachment of platelets via a bridge of fibrinogen :: 8839849 :: Homo sapiens
|
| Functional Information / Functions in biological process of |
- Adhesion :: Yes :: Fibulin-1 has inhibitory effects on the cell attachment and spreading promoted by fibronectin. :: 11792823 :: Homo sapiens
- Development/Organogenesis/Tooth :: Yes :: :: 8850569 :: Mus musculus
- Motility/Suppressor :: Yes :: Fibulin-1 suppresses fibronectin-regulated cell adhesion and motility. :: 11792823 :: Homo sapiens
- " :: Yes :: :: 9466671 :: Homo sapiens
|
| General Information / Protein name |
- Most widely accepted :: fibulin-1 :: :: 2269669 :: Homo sapiens
- Related proteins :: fibulin-2 :: NM_001998 :: 8245130 :: Homo sapiens
- " :: fibulin-3 :: S1-5 :: 9106159 :: Homo sapiens
- Synonym :: BM-90 :: :: 2269669 :: Mus musculus
- " :: fibulin-1 :: :: 12778127 :: Homo sapiens
|
| Genetic Information / cDNA sequence ID numbers |
- Accession no. :: NM_001996 :: :: :: Homo sapiens
- GI no. :: 4503662 :: :: :: Homo sapiens
|
| Genetic Information |
|
| Genetic Information / Mutations |
- Gene Knockout :: Yes :: Fibulin-1-deficient mice die at or near birth with massive hemorrhage, dilation and ruptures in endothelial lining of small vessels but not larger vessels. Kidneys display malformation of glomeruli and disorganization of podocytes. A delayed development of lung alveoli suggested impairment in lung inflation. :: 11564885 :: Mus musculus
|
| Genetic Information |
- Number of exons :: 18 :: :: 10037144 :: Mus musculus
- OMIM number :: 135820 :: :: :: Homo sapiens
- Transcript size :: 2156 :: :: :: Homo sapiens
- UniGene cluster number :: Dr.560 :: Dr.560 :: :: Danio rerio (zebrafish)
- " :: Hs.79732 :: Hs.79732 :: :: Homo sapiens
- " :: Mm.22626 :: Mm.22626 :: :: Mus musculus
|
| Structural Information / Extinction coefficient |
- [280 nm, 1%, 1 cm] :: 0.517 :: fibulin-1D variant (includes signal peptide) :: :: Homo sapiens
|
| Structural Information / Glycosylated |
- O-linked :: Yes :: :: 2269669 :: Homo sapiens
|
| Structural Information |
- Modular domain structure :: Anaphylotoxin-like domain (3) :: PF01821 :: :: Homo sapiens
- " :: Yes :: ANATO (3); Anaphylotoxin-like domain :: 2269669 :: Homo sapiens
- " :: Yes :: EGF-like (9) :: 2269669 :: Homo sapiens
- " :: Yes :: EGF_CA (8) :: 2269669 :: Homo sapiens
|
| Structural Information / Protein sequence ID numbers |
- Accession no. :: NP_001987.1 :: :: :: Homo sapiens
- GI no. :: 4503663 :: :: :: Homo sapiens
|
| Structural Information / Size |
- Molecular mass/core protein [Da] :: 70950.8 :: fibulin-1D variant (includes signal peptide) :: :: Homo sapiens
|
| Structural Information / Variant forms |
|
Search Path: MendelBase