Search Path: MendelBase Query: ^low density lipoprotein receptor-related protein 2 (LRP2, megalin) *| Legend: Attribute :: answer :: comment :: PubMed ID :: Species

low density lipoprotein receptor-related protein 2 (LRP2, megalin) Expression Information Serial Analysis of Gene Expression [SAGE] :: Yes :: SAGE library data ::  :: Homo sapiens  Expression Information / Tissue Localization Adult/Urogenital/Efferent duct :: Yes ::  :: 8862787 :: Rattus  Adult/Urogenital/Epididymis :: Yes ::  :: 8862787 :: Rattus  Embryo/Intraembryonic/Brain Embryonic/Choroid plexus :: Yes ::  :: 7803716 :: Mus musculus  Functional Information / Binds to or Interacts with Protein/Name of protein that it binds :: ankyrin-repeat family A protein (ANKRA) :: ANKRA interacts with the cytoplasmic tail of megalin. :: 11095640 :: Mus musculus    "    :: apolipoprotein B100 ::  :: 7642623 :: Mus musculus    "    :: apolipoprotein J (apoJ); clusterin :: Kd = 14.2 nM :: 7768901 :: Sus scrofa (pig)    "    :: atrophin-1-interacting protein-1 :: atrophin-1-interacting protein-1 is related to MAGI-1 :: 11274227 :: Mus musculus    "    :: cation-independent mannose 6-phosphate/insulin-like growth factor II-receptor (CIMPR) ::  :: 12121845 :: Rattus    "    :: Disabled protein 2 (Dab2) :: The third PsiXNPXY motif of the megalin cytoplasmic domain is most probably involved in this interaction of Dab2 and megalin. :: 10769163 :: Homo sapiens    "    :: GIPC :: GIPC is a component of G protein-mediated signaling pathways that interacts with the cytoplasmic tail of megalin. :: 11912251 :: Mus musculus    "    :: megalin-binding protein (MegBP) ::  :: 12508107 :: Mus musculus    "    :: membrane-associated guanylate kinase-1 :: MAGI-1 is related to atrophin-1-interacting protein-1 :: 11274227 :: Mus musculus    "    :: myoglobin :: Kd = 2.0 micro M. Megalin works in conjuction with cublin to mediate myoglobin uptake in the renal proximal tubule. :: 12724130 :: Mus musculus    "    :: Parathyroid hormone (PTH) :: Megalin is involved in the renal catabolism of PTH and potentially antagonizes PTH/PTHrP receptor activity in the proximal tubular epithelium. :: 10026179 :: Mus musculus    "    :: plasma retinol-binding protein (RBP) ::  :: 10203351 :: Rattus    "    :: PSD-95 :: The membrane-associated guanylate kinase family member PSD-95 binds to the megalin cytoplasmic domain. :: 12713445 :: Homo sapiens    "    :: SEMCAP-1/GIPC ::  :: 10827173 :: Homo sapiens    "    :: sonic hedgehog (SHH) ::  :: 11964399 :: Rattus    "    :: SVS-II :: the megalin- (LRP-2) binding site was mapped to a stretch of repeated 13-residue modules located in the central portion of the SVS-II polypeptide :: 10026171 :: Sus scrofa (pig)    "    :: thrombospondin-1 ::  :: 7775583 :: Rattus    "    :: vitamin D-binding protein ::  :: 10052453 :: Mus musculus  Functional Information / Functions in biological process of Transport or Trafficking/Endocytosis :: Yes :: megalin acts in conjunction with cubilin to mediate endocytosis of transferrin thereby facilitating iron uptake. :: 11606717 :: Mus musculus    "    :: Yes ::  :: 11229868 :: Homo sapiens  Transport or Trafficking/Lipoprotein :: Yes :: LRP-2/megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins (HDL) :: 10766831 :: Rattus    "    :: Yes :: LRP-2/megalin mediates endocytosis of low density lipoproteins (LDL) :: 7642623 :: Mus musculus  Transport or Trafficking/Transcytosis :: Yes :: megalin mediates transcytosis of plasma retinol binding protein (RBP) combined with vitamin A (retinol) through renal proximal tubule cells.  :: 11274224 :: Rattus  General Information / Protein name Synonym :: brushin ::  :: 2449897 :: Mus musculus    "    :: gp330 ::  :: 7579068 :: Rattus    "    :: Low density lipoprotein receptor related protein-2 (LRP-2/LRP2) ::  :: 7959795 :: Rattus  Genetic Information / cDNA sequence ID numbers Accession no. :: NM_030827 ::  ::  :: Rattus norvegicus  GI no. :: 13562117 ::  ::  :: Rattus norvegicus  Genetic Information cDNA sequence ID numbers :: AF197160.1 GI:7381455 :: AF197160.1 GI:7381455 ::  :: Mus musculus    "    :: NM_004525.1 GI:6806918 :: NM_004525.1 GI:6806918 :: 96305376 :: Homo sapiens  Chromosomal localization :: 2q24-q31 ::  :: 7959795 :: Homo sapiens  Gene symbol [map element] :: Lrp2 ::  ::  :: Rattus norvegicus    "    :: LRP2 :: 4036 ::  :: Homo sapiens  LocusLink ID number :: 4036 :: low density lipoprotein-related protein 2 ; 4036 ::  :: Homo sapiens    "    :: 29216 ::  ::  :: Rattus norvegicus  Genetic Information / Mutations Gene Knockout :: Yes :: Homozygous knockout mice manifested abnormalities in epithelial tissues including lung and kidney that normally express the protein. The mice died perinatally from respiratory insufficiency. In brain, impaired proliferation of neuroepithelium produced a holoprosencephalic syndrome. :: 8710893  :: Mus musculus  Genetic Information OMIM number :: *600073 :: *600073 ::  :: Homo sapiens  Transcript size :: 15438 ::  ::  :: Rattus norvegicus  UniGene cluster number :: Hs.153595 :: Hs.153595 ::  :: Homo sapiens  Structural Information / Protein sequence ID numbers Accession no. :: NP_110454.1 ::  ::  :: Rattus norvegicus  GI no. :: 13562118 ::  ::  :: Rattus norvegicus  Record Count: 45 Contributors: Scott Argraves; dbSieve1; Total Protein Count: 1 Total Record Count: 45 Please review our Disclaimers and Terms of Use Agreements. Copyright 2000 Array Genetics, Inc., All Rights Reserved.